纯度:>98% by HPLC;NMR (Conforms)
分子式:C5H4FN3O2
分子量:157.10
溶剂:DMSO (30 mg/ml) Water (12 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Viral RNA-dependent RNA polymerase inhibitor
Function / Pharmacology:Favipiravir is an inhibitor of Influenza viruses A, B, and C (IC50’s: A = 0.03-0.20 μg/mL H1N1, 0.01-0.30 H2N2, 0.08-0.48 H3N2, 0.14-0.15 H4N2, 0.24-1.60 H7N2, 0.20-0.82 H5N1, 0.35 H1N2; B = 0.04-0.09 μg/mL; C = 0.03-0.06 μg/mL) as well as strains resistant to adamantane-type antivirals, oseltamivir, and zanamivir.1,2,3 It displayed no cytotoxicity in a variety of cells. Favipiravir selectively inhibits viral RNA-dependent RNA polymerase.4 Favipiravir has also shown activity against other viruses including arena, phlebo, hanta, flavi, entero, alpha, respiratory syncytial, and noroviruses.5 In clinical trials for treatment of SARS-CoV-2.6,7