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Ganetespib
- 英文名称：Ganetespib
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11222
- cas：888216-25-9
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11222 |
| 用途 | 科研检测 |
| 英文名称 | Ganetespib |
| 包装规格 | 1MG |
| CAS编号 | 888216-25-9 |
| 别名 | Ganetespib |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C20H20N4O3
分子量:364.40
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):HSP90 inhibitor
Function / Pharmacology:Ganetespib is an inhibitor of heat shock protein 90 (IC50 = 19 nM, canine C2 malignant mast cells; 4 nM, canine BR malignant mast cells) binding to the N-terminal ATP site.1 It displayed potent cytotoxicity against a panel of 57 transformed cell lines of both hematologic and solid tumors with IC50’s between 14 and 280 nM.2 Ganetespib enhanced T-cell-mediated killing of human melanoma cells and potentiated responses to anti-CTLA4 and anti-PD1 therapy via upregulation of interferon response genes.3 In multiple clinical trials for various cancers.
分子式:C20H20N4O3
分子量:364.40
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):HSP90 inhibitor
Function / Pharmacology:Ganetespib is an inhibitor of heat shock protein 90 (IC50 = 19 nM, canine C2 malignant mast cells; 4 nM, canine BR malignant mast cells) binding to the N-terminal ATP site.1 It displayed potent cytotoxicity against a panel of 57 transformed cell lines of both hematologic and solid tumors with IC50’s between 14 and 280 nM.2 Ganetespib enhanced T-cell-mediated killing of human melanoma cells and potentiated responses to anti-CTLA4 and anti-PD1 therapy via upregulation of interferon response genes.3 In multiple clinical trials for various cancers.
