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IACS-010759
- 英文名称:IACS-010759
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11223
- cas:1570496-34-2
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11223 |
用途 | 科研检测 |
英文名称 | IACS-010759 |
包装规格 | 1MG |
CAS编号 | 1570496-34-2 |
别名 | IACS-010759 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C25H25F3N6O4S
分子量:562.57
溶剂:DMSO (>25 mg/ml)
性状:White to off-white solid
存储:-20°C
Activity (short version):Mitochondrial Complex I Inhibitor
Function / Pharmacology:IACS-010759 (1570496-34-2) is a potent (IC50 = 1.1 nM isolated mouse complex I) and selective inhibitor of complex I of the mitochondrial electron transport chain (OXPHOS). IACS-010759 displayed in vivo efficacy in glycolysis-deficient glioblastoma and AML models without cytotoxicity to normal cells. The lack of cytotoxicity to normal cells, as opposed to other complex I inhibitors, is attributed to its unique binding location on complex I.2 Complex I inhibition by IACS-010759 causes an ROS-induced decrease in the endogenous PP2A inhibitor CIP2A leading to cell death.3 It has also displayed potential in various chemotherapy-resistant cancer cell lines.4-7
分子式:C25H25F3N6O4S
分子量:562.57
溶剂:DMSO (>25 mg/ml)
性状:White to off-white solid
存储:-20°C
Activity (short version):Mitochondrial Complex I Inhibitor
Function / Pharmacology:IACS-010759 (1570496-34-2) is a potent (IC50 = 1.1 nM isolated mouse complex I) and selective inhibitor of complex I of the mitochondrial electron transport chain (OXPHOS). IACS-010759 displayed in vivo efficacy in glycolysis-deficient glioblastoma and AML models without cytotoxicity to normal cells. The lack of cytotoxicity to normal cells, as opposed to other complex I inhibitors, is attributed to its unique binding location on complex I.2 Complex I inhibition by IACS-010759 causes an ROS-induced decrease in the endogenous PP2A inhibitor CIP2A leading to cell death.3 It has also displayed potential in various chemotherapy-resistant cancer cell lines.4-7