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IACS-010759
  • 英文名称:IACS-010759
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11223
  • cas:1570496-34-2
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-23
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11223
用途 科研检测
英文名称 IACS-010759
包装规格 1MG
CAS编号 1570496-34-2
别名 IACS-010759
纯度 98+%
分子式
是否进口
纯度:>98% by HPLC;NMR (Conforms)
分子式:C25H25F3N6O4S
分子量:562.57
溶剂:DMSO (>25 mg/ml)
性状:White to off-white solid
存储:-20°C
Activity (short version):Mitochondrial Complex I Inhibitor
Function / Pharmacology:IACS-010759 (1570496-34-2) is a potent (IC50 = 1.1 nM isolated mouse complex I) and selective inhibitor of complex I of the mitochondrial electron transport chain (OXPHOS). IACS-010759 displayed in vivo efficacy in glycolysis-deficient glioblastoma and AML models without cytotoxicity to normal cells. The lack of cytotoxicity to normal cells, as opposed to other complex I inhibitors, is attributed to its unique binding location on complex I.2 Complex I inhibition by IACS-010759 causes an ROS-induced decrease in the endogenous PP2A inhibitor CIP2A leading to cell death.3 It has also displayed potential in various chemotherapy-resistant cancer cell lines.4-7
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