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DAPT
- 英文名称:DAPT
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11246
- cas:208255-80-5
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11246 |
用途 | 科研检测 |
英文名称 | DAPT |
包装规格 | 1MG |
CAS编号 | 208255-80-5 |
别名 | DAPT |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C23H26F2N2O4
分子量:432.46
溶剂:DMSO 18 mg/ml
性状:White solid
存储:-20°C
Activity (short version):γ-secretase inhibitor
Function / Pharmacology:Inhibitor of γ-secretase (IC50 in human primary neurons = 115 nM for total Aβ or 200 nM for Aβ42 specifically)1. Oral administration of DAPT has been shown to reduce levels of Aβ in brain extract, cerebrospinal fluid and plasma from mice and rats.2,3 DAPT blocks Notch signaling which promotes neuronal differentiation of precur-sor cells.4 Enhances iPS cells without oncogenes KLF4 and CMYC5. Cell permeable.
分子式:C23H26F2N2O4
分子量:432.46
溶剂:DMSO 18 mg/ml
性状:White solid
存储:-20°C
Activity (short version):γ-secretase inhibitor
Function / Pharmacology:Inhibitor of γ-secretase (IC50 in human primary neurons = 115 nM for total Aβ or 200 nM for Aβ42 specifically)1. Oral administration of DAPT has been shown to reduce levels of Aβ in brain extract, cerebrospinal fluid and plasma from mice and rats.2,3 DAPT blocks Notch signaling which promotes neuronal differentiation of precur-sor cells.4 Enhances iPS cells without oncogenes KLF4 and CMYC5. Cell permeable.