纯度:98% by TLC [1% methanol in methylene chloride Rf = 0.35],;NMR (Conforms)
分子式:C21 H17 Cl3 N4 O S
分子量:479.81
溶剂:DMSO (25 mg/ml)
性状:Beige solid
存储:-20°C
Activity (short version):eIF2α Phosphatase inhibitor
Function / Pharmacology:Endoplasmic reticulum (ER) stress inhibitor. Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic initiation factor 2 subunit alpha (eIF2α).1 It has been found to interact with the anti-apoptotic protein Bcl-2 offering protection from the apoptotic and autophagic effects that result from loss of Bcl-2 function.2 Salubrinal blocked NFATc1 expression and osteoclast differentiation by RANKL via phosphorylation of eLF2α resulting in a decrease of global protein synthesis. It efficiently blocked osteoporosis in a mouse model treated with RANKL.3