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Tubastatin A · HCl
- 英文名称：Tubastatin A · HCl
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11260
- cas：1310693-92-5
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11260 |
| 用途 | 科研检测 |
| 英文名称 | Tubastatin A · HCl |
| 包装规格 | 1MG |
| CAS编号 | 1310693-92-5 |
| 别名 | Tubastatin A · HCl |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:99% by HPLC,;NMR (Conforms)
分子式:C20H22N3O2 · HCl
分子量:371.86
溶剂:DMSO or water
性状:solid
存储:-20°C
Activity (short version):HDAC-6 inhibitor
Function / Pharmacology:Tubastatin A is a potent and highly selective inhibitor of HDAC6 (IC50 = 15 nM, >1000-fold selectivity against other HDAC isoforms, approx. 60-fold versus HDAC8).1 It displayed anti-inflammatory and anti-rheumatic effects in Freund’s competitive adjuvant induced animal model of inflammation.2 Tubastatin A inhibited TNF-α (IC50 = 272 nM) and IL-6 (IC50 = 712 nM) in LPS stimulated human THP-1 macrophages.2 Tubastatin A has also been shown to have therapeutic potential for treatment of Alzheimers disease via altered amloid-β load and reduced tau hyperphosphorylation.3,4,5
分子式:C20H22N3O2 · HCl
分子量:371.86
溶剂:DMSO or water
性状:solid
存储:-20°C
Activity (short version):HDAC-6 inhibitor
Function / Pharmacology:Tubastatin A is a potent and highly selective inhibitor of HDAC6 (IC50 = 15 nM, >1000-fold selectivity against other HDAC isoforms, approx. 60-fold versus HDAC8).1 It displayed anti-inflammatory and anti-rheumatic effects in Freund’s competitive adjuvant induced animal model of inflammation.2 Tubastatin A inhibited TNF-α (IC50 = 272 nM) and IL-6 (IC50 = 712 nM) in LPS stimulated human THP-1 macrophages.2 Tubastatin A has also been shown to have therapeutic potential for treatment of Alzheimers disease via altered amloid-β load and reduced tau hyperphosphorylation.3,4,5
