纯度:98% by TLC [3:2 ethyl acetate : hexane; Rf = 0.15];NMR (Conforms)
分子式:C27H46O2
分子量:402.66
溶剂:DMSO or Ethanol
性状:White or pale yellow solid
存储:-20°C
Activity (short version):Bile acid precursor
Function / Pharmacology:Metabolite resulting from the action of cholesterol 7 alpha-hydroxylase on cholesterol. 7α-Hydroxycholesterol is the first intermediate and a rate-limiting step in the major pathway for bile acid synthesis in humans. A pro-inflammatory mediator which upregulates production of CCL2 and MMP9 in macrophages and may promote progression of atherosclerosis.2,3 Possible biomarker for cellular lipid peroxidation.4