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20(S)-Hydroxycholesterol
  • 英文名称:20(S)-Hydroxycholesterol
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11267
  • cas:516-72-3
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-23
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11267
用途 科研检测
英文名称 20(S)-Hydroxycholesterol
包装规格 1MG
CAS编号 516-72-3
别名 20(S)-Hydroxycholesterol
纯度 98+%
分子式
是否进口
纯度:98% by TLC,;NMR (Conforms)
分子式:C27H46O2
分子量:402.66
溶剂:DMSO or Ethanol
性状:White solid
存储:-20°C
Activity (short version):Smoothened activator
Function / Pharmacology:20-(S)-Hydroxycholesterol is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal stem cells mediated via a non-LXR dependent pathway.2 The osteogenic effects of 20-(S)-hydroxycholesterol have been shown to be mediated by activation of hedgehog signaling and expression of genes associated with Notch signaling.3 Activation of Hedgehog is mediated via binding of 20(S)-hydroxycholesterol to Smoothened at a site distinct from the cyclopamine binding site.4,5
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