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20(S)-Hydroxycholesterol
- 英文名称:20(S)-Hydroxycholesterol
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11267
- cas:516-72-3
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11267 |
用途 | 科研检测 |
英文名称 | 20(S)-Hydroxycholesterol |
包装规格 | 1MG |
CAS编号 | 516-72-3 |
别名 | 20(S)-Hydroxycholesterol |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C27H46O2
分子量:402.66
溶剂:DMSO or Ethanol
性状:White solid
存储:-20°C
Activity (short version):Smoothened activator
Function / Pharmacology:20-(S)-Hydroxycholesterol is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal stem cells mediated via a non-LXR dependent pathway.2 The osteogenic effects of 20-(S)-hydroxycholesterol have been shown to be mediated by activation of hedgehog signaling and expression of genes associated with Notch signaling.3 Activation of Hedgehog is mediated via binding of 20(S)-hydroxycholesterol to Smoothened at a site distinct from the cyclopamine binding site.4,5
分子式:C27H46O2
分子量:402.66
溶剂:DMSO or Ethanol
性状:White solid
存储:-20°C
Activity (short version):Smoothened activator
Function / Pharmacology:20-(S)-Hydroxycholesterol is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal stem cells mediated via a non-LXR dependent pathway.2 The osteogenic effects of 20-(S)-hydroxycholesterol have been shown to be mediated by activation of hedgehog signaling and expression of genes associated with Notch signaling.3 Activation of Hedgehog is mediated via binding of 20(S)-hydroxycholesterol to Smoothened at a site distinct from the cyclopamine binding site.4,5