纯度:98% by TLC,;NMR (Conforms)
分子式:C27H46O2
分子量:402.66
溶剂:DMSO or Ethanol
性状:White solid
存储:-20°C
Activity (short version):Smoothened activator
Function / Pharmacology:20-(S)-Hydroxycholesterol is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal stem cells mediated via a non-LXR dependent pathway.2 The osteogenic effects of 20-(S)-hydroxycholesterol have been shown to be mediated by activation of hedgehog signaling and expression of genes associated with Notch signaling.3 Activation of Hedgehog is mediated via binding of 20(S)-hydroxycholesterol to Smoothened at a site distinct from the cyclopamine binding site.4,5