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7-Cl-O-Nec1
- 英文名称：7-Cl-O-Nec1
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11271
- cas：852391-15-2
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11271 |
| 用途 | 科研检测 |
| 英文名称 | 7-Cl-O-Nec1 |
| 包装规格 | 1MG |
| CAS编号 | 852391-15-2 |
| 别名 | 7-Cl-O-Nec1 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by TLC (5% methanol / methylene chloride; Rf = 0.55),;NMR (Conforms)
分子式:C13H12ClN3O2
分子量:277.71
溶剂:DMSO (25 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Rip1 blocker
Function / Pharmacology:Necrostatin-1 analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2 7-Cl-O-Nec-1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1).3,4 7-Cl-O-Nec-1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50 = 210 nM vs. EC50 = 490 nM), no non-specific cytotoxicity at high concentrations (100 μM) and reasonable pharmacokinetic characteristics when used in mice.2 7-Cl-O-Nec-1 is recommended for cellular and in vivo use over Necrostatin-1.5
分子式:C13H12ClN3O2
分子量:277.71
溶剂:DMSO (25 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Rip1 blocker
Function / Pharmacology:Necrostatin-1 analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2 7-Cl-O-Nec-1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1).3,4 7-Cl-O-Nec-1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50 = 210 nM vs. EC50 = 490 nM), no non-specific cytotoxicity at high concentrations (100 μM) and reasonable pharmacokinetic characteristics when used in mice.2 7-Cl-O-Nec-1 is recommended for cellular and in vivo use over Necrostatin-1.5
