纯度:98% by HPLC, NMR (Confirms)
分子式:C5H12N8 · 2HCl
分子量:257.13
溶剂:water (>25 mg/ml) DMSO (?)
性状:White solid
存储:-20°C
Activity (short version):Polyamine biosynthesis inhibitor / SAM decarboxylase inhibitor
Function / Pharmacology:Mitoguazone is a potent and reversible inhibitor of S-adenosylmethionine decarboxylase (SAMD or AdoMetDC).1,2 SAMD is a component of the polyamine-biosynthetic pathway, thus inhibition may lead to changes in polyamine metabolism.3 Mitoguazone has also been shown to inhibit diamine oxidase and induce spermidine/spermine N-acetyltransferase.4,5 Mitoguazone has been looked at as a potential anti-cancer treatment because of it’s ability to inhibit polyamine synthesis.6