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POB
- 英文名称:POB
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11278
- cas:946135-39-3
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-12
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11278 |
用途 | 科研检测 |
英文名称 | POB |
包装规格 | 1MG |
CAS编号 | 946135-39-3 |
别名 | POB |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC, NMR (Confirms)
分子式:C19H31N3O6
分子量:397.47
溶剂:Ethanol (25 mg/ml) DMSO (25 mg/ml) Water (2 mg/ml)
性状:White solid
存储:RT
Activity (short version):Ornithine decarboxylase inhibitor
Function / Pharmacology:Pyridoxal 5’-phosphate – dependent ornithine decarboxylase (ODC) is a key enzyme involved in polyamine synthesis and a potential cancer drug target. POB is a transition state-based, cell permeable pro-drug inhibitor of ODC. Intracellularly, POB is phosphorylated by pyridoxal kinase and the methyl ester hydrolyzed. This active inhibitor most likely binds apo-ODC resulting in greatly reduced ODC activity and inhibition of cellular proliferation. POB was able to inhibit proliferation in a wide variety of tumor cell lines: LN229 (IC50 = 50 μM), Jurkat, COS7, SW2 and both high and low-grade glioblastoma multiforme. More potent than DFMO.
分子式:C19H31N3O6
分子量:397.47
溶剂:Ethanol (25 mg/ml) DMSO (25 mg/ml) Water (2 mg/ml)
性状:White solid
存储:RT
Activity (short version):Ornithine decarboxylase inhibitor
Function / Pharmacology:Pyridoxal 5’-phosphate – dependent ornithine decarboxylase (ODC) is a key enzyme involved in polyamine synthesis and a potential cancer drug target. POB is a transition state-based, cell permeable pro-drug inhibitor of ODC. Intracellularly, POB is phosphorylated by pyridoxal kinase and the methyl ester hydrolyzed. This active inhibitor most likely binds apo-ODC resulting in greatly reduced ODC activity and inhibition of cellular proliferation. POB was able to inhibit proliferation in a wide variety of tumor cell lines: LN229 (IC50 = 50 μM), Jurkat, COS7, SW2 and both high and low-grade glioblastoma multiforme. More potent than DFMO.