纯度:98% by HPLC, NMR (Confirms)
分子式:C19H31N3O6
分子量:397.47
溶剂:Ethanol (25 mg/ml) DMSO (25 mg/ml) Water (2 mg/ml)
性状:White solid
存储:RT
Activity (short version):Ornithine decarboxylase inhibitor
Function / Pharmacology:Pyridoxal 5’-phosphate – dependent ornithine decarboxylase (ODC) is a key enzyme involved in polyamine synthesis and a potential cancer drug target. POB is a transition state-based, cell permeable pro-drug inhibitor of ODC. Intracellularly, POB is phosphorylated by pyridoxal kinase and the methyl ester hydrolyzed. This active inhibitor most likely binds apo-ODC resulting in greatly reduced ODC activity and inhibition of cellular proliferation. POB was able to inhibit proliferation in a wide variety of tumor cell lines: LN229 (IC50 = 50 μM), Jurkat, COS7, SW2 and both high and low-grade glioblastoma multiforme. More potent than DFMO.