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POB
  • 英文名称:POB
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11278
  • cas:946135-39-3
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-12
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11278
用途 科研检测
英文名称 POB
包装规格 1MG
CAS编号 946135-39-3
别名 POB
纯度 98+%
分子式
是否进口
纯度:98% by HPLC, NMR (Confirms)
分子式:C19H31N3O6
分子量:397.47
溶剂:Ethanol (25 mg/ml) DMSO (25 mg/ml) Water (2 mg/ml)
性状:White solid
存储:RT
Activity (short version):Ornithine decarboxylase inhibitor
Function / Pharmacology:Pyridoxal 5’-phosphate – dependent ornithine decarboxylase (ODC) is a key enzyme involved in polyamine synthesis and a potential cancer drug target. POB is a transition state-based, cell permeable pro-drug inhibitor of ODC. Intracellularly, POB is phosphorylated by pyridoxal kinase and the methyl ester hydrolyzed. This active inhibitor most likely binds apo-ODC resulting in greatly reduced ODC activity and inhibition of cellular proliferation. POB was able to inhibit proliferation in a wide variety of tumor cell lines: LN229 (IC50 = 50 μM), Jurkat, COS7, SW2 and both high and low-grade glioblastoma multiforme. More potent than DFMO.
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