![]() |
CB-839
- 英文名称:CB-839
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11280
- cas:1439399-58-2
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-16
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11280 |
用途 | 科研检测 |
英文名称 | CB-839 |
包装规格 | 1MG |
CAS编号 | 1439399-58-2 |
别名 | CB-839 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>97% by HPLC: Agilent Poroshell 120 C18, 80/20 MeOH/water, 0.8 mL/min, 245 and 270 nm.;NMR (Conforms)
分子式:C26H24F3N7O3S
分子量:571.57
溶剂:DMSO
性状:Pale yellow solid
存储:-20°C
Activity (short version):Glutaminase inhibitor
Function / Pharmacology:CB-839 is a potent (IC50 = 24 nM), selective and orally bioavailable inhibitor of glutaminase (KGA and GAC).1 CB-839 displayed an antiproliferative effect in the triple-negative breast cancer cell line, HCC-1806, but no activity in the estrogen receptor-positive cell line T47D. CB-839 was able to cause proliferation arrest and apoptosis in acute myeloid leukemia cells without causing cytotoxicity against normal human CD34(+) progenitors.2 Aspartate-glutamate carrier 1 (AGC1) inhibition can synergize with CB-839 to limit tumor growth.3
分子式:C26H24F3N7O3S
分子量:571.57
溶剂:DMSO
性状:Pale yellow solid
存储:-20°C
Activity (short version):Glutaminase inhibitor
Function / Pharmacology:CB-839 is a potent (IC50 = 24 nM), selective and orally bioavailable inhibitor of glutaminase (KGA and GAC).1 CB-839 displayed an antiproliferative effect in the triple-negative breast cancer cell line, HCC-1806, but no activity in the estrogen receptor-positive cell line T47D. CB-839 was able to cause proliferation arrest and apoptosis in acute myeloid leukemia cells without causing cytotoxicity against normal human CD34(+) progenitors.2 Aspartate-glutamate carrier 1 (AGC1) inhibition can synergize with CB-839 to limit tumor growth.3