纯度:98% by HPLC, NMR (Confirms)
分子式:C19H18F3N5OS
分子量:421.44
溶剂:Ethanol (2 mg/ml), DMSO (5 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):SCD1 inhibitor
Function / Pharmacology:MF-438 is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) - IC50 = 2.3 nM.1 MF-438 was potent in an in vivo mouse liver PD assay (ED50 between 1 and mg/kg).1 Cancer initiating cells (CSC-like) were shown to much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model.2 MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models.