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MF-438
- 英文名称:MF-438
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11281
- cas:921605-87-0
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11281 |
用途 | 科研检测 |
英文名称 | MF-438 |
包装规格 | 1MG |
CAS编号 | 921605-87-0 |
别名 | MF-438 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC, NMR (Confirms)
分子式:C19H18F3N5OS
分子量:421.44
溶剂:Ethanol (2 mg/ml), DMSO (5 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):SCD1 inhibitor
Function / Pharmacology:MF-438 is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) - IC50 = 2.3 nM.1 MF-438 was potent in an in vivo mouse liver PD assay (ED50 between 1 and mg/kg).1 Cancer initiating cells (CSC-like) were shown to much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model.2 MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models.
分子式:C19H18F3N5OS
分子量:421.44
溶剂:Ethanol (2 mg/ml), DMSO (5 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):SCD1 inhibitor
Function / Pharmacology:MF-438 is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) - IC50 = 2.3 nM.1 MF-438 was potent in an in vivo mouse liver PD assay (ED50 between 1 and mg/kg).1 Cancer initiating cells (CSC-like) were shown to much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model.2 MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models.