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Lonidamine
  • 英文名称:Lonidamine
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11284
  • cas:50264-69-2
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-23
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11284
用途 科研检测
英文名称 Lonidamine
包装规格 1MG
CAS编号 50264-69-2
别名 Lonidamine
纯度 98+%
分子式
是否进口
纯度:98% by TLC,;NMR (Conforms)
分子式:C15H10Cl2N2O2
分子量:321.16
溶剂:DMSO (25 mg/ml)
性状:white solid
存储:-20°C
Activity (short version):Cancer cell metabolism inhibitor
Function / Pharmacology:Lonidamine was originally investigated as an antispermatogenic agent.1 Lonidamine has been shown to decrease oxygen consumption as well as aerobic and anaerobic glycolysis in tumor cells leading to apoptosis.2 These effects have been attributed to the ability of lonidamine to inhibit mitochondrially bound hexokinase (IC50 = 90 μM for aerobic glycolysis, 45 μM for anaerobic glycolysis using Ehrlich ascites tumor cells)2. The apoptotic effects of lonidamine have also been attributed to its ability to disrupt the mitochondrial transmembrane potential3, intracellular acidification by inhibition of lactate efflux4, and inhibition of mitochondrial pyruvate (MCP) and monocarboxylate transporter (MCT)5.
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