![]() |
Lonidamine
- 英文名称:Lonidamine
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11284
- cas:50264-69-2
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11284 |
用途 | 科研检测 |
英文名称 | Lonidamine |
包装规格 | 1MG |
CAS编号 | 50264-69-2 |
别名 | Lonidamine |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C15H10Cl2N2O2
分子量:321.16
溶剂:DMSO (25 mg/ml)
性状:white solid
存储:-20°C
Activity (short version):Cancer cell metabolism inhibitor
Function / Pharmacology:Lonidamine was originally investigated as an antispermatogenic agent.1 Lonidamine has been shown to decrease oxygen consumption as well as aerobic and anaerobic glycolysis in tumor cells leading to apoptosis.2 These effects have been attributed to the ability of lonidamine to inhibit mitochondrially bound hexokinase (IC50 = 90 μM for aerobic glycolysis, 45 μM for anaerobic glycolysis using Ehrlich ascites tumor cells)2. The apoptotic effects of lonidamine have also been attributed to its ability to disrupt the mitochondrial transmembrane potential3, intracellular acidification by inhibition of lactate efflux4, and inhibition of mitochondrial pyruvate (MCP) and monocarboxylate transporter (MCT)5.
分子式:C15H10Cl2N2O2
分子量:321.16
溶剂:DMSO (25 mg/ml)
性状:white solid
存储:-20°C
Activity (short version):Cancer cell metabolism inhibitor
Function / Pharmacology:Lonidamine was originally investigated as an antispermatogenic agent.1 Lonidamine has been shown to decrease oxygen consumption as well as aerobic and anaerobic glycolysis in tumor cells leading to apoptosis.2 These effects have been attributed to the ability of lonidamine to inhibit mitochondrially bound hexokinase (IC50 = 90 μM for aerobic glycolysis, 45 μM for anaerobic glycolysis using Ehrlich ascites tumor cells)2. The apoptotic effects of lonidamine have also been attributed to its ability to disrupt the mitochondrial transmembrane potential3, intracellular acidification by inhibition of lactate efflux4, and inhibition of mitochondrial pyruvate (MCP) and monocarboxylate transporter (MCT)5.