纯度:>98%,;NMR (Conforms)
分子式:C12H14N2O2
分子量:218.25
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):IDO modulator / tryptophan mimetic
Function / Pharmacology:Indoximod is a modulator of indoleamine 2,3-dioxygenase (IDO) activity.1 IDO can be used by tumors to avoid elimination by the host immune response2,3, thus inhibition of IDO is an interesting cancer therapeutic option. Indoximod is not a direct inhibitor of IDO, but instead targets the IDO gene leading to downstream effects.3 IDO-mediated catabolism of tryptophan inhibits the immunoregulatory kinases mTOR and PKC5. This is relieved by Indoximod acting as a potent tryptophan mimetic restoring mTOR and PKC signaling.4