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STF-31
- 英文名称：STF-31
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11291
- cas：724741-75-7
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-07-16
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11291 |
| 用途 | 科研检测 |
| 英文名称 | STF-31 |
| 包装规格 | 1MG |
| CAS编号 | 724741-75-7 |
| 别名 | STF-31 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC
分子式:C23H25N3O3S
分子量:423.53
溶剂:DMSO (25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):NAMPT inhibitor
Function / Pharmacology:STF31 is an inhibitor of glucose transporter 1 (GLUT1; IC50 = 1 μM)1 and NAMPT3. Inhibition of glucose transporters to target It has been shown to kill renal cell carcinoma cells (the majority of which lack the von Hippel-Lindau suppressor gene) without toxicity to normal cells. The target of STF31 anti-tumor activity has recently been questioned via use of large-scale cancer cell-line profiling.2 This profiling indicated that nicotinamide phosphoribosyltransferase (NAMPT) was in fact the target of STF31. The inhibition of NAMPT by STF31 was confirmed via biochemical assay against recombinant NAMPT. The ability of STF31 to inhibit NAMPT had been previously displayed (IC50 = 19 nM).3
分子式:C23H25N3O3S
分子量:423.53
溶剂:DMSO (25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):NAMPT inhibitor
Function / Pharmacology:STF31 is an inhibitor of glucose transporter 1 (GLUT1; IC50 = 1 μM)1 and NAMPT3. Inhibition of glucose transporters to target It has been shown to kill renal cell carcinoma cells (the majority of which lack the von Hippel-Lindau suppressor gene) without toxicity to normal cells. The target of STF31 anti-tumor activity has recently been questioned via use of large-scale cancer cell-line profiling.2 This profiling indicated that nicotinamide phosphoribosyltransferase (NAMPT) was in fact the target of STF31. The inhibition of NAMPT by STF31 was confirmed via biochemical assay against recombinant NAMPT. The ability of STF31 to inhibit NAMPT had been previously displayed (IC50 = 19 nM).3
