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L-Buthionine Sulfoximine
  • 英文名称:L-Buthionine Sulfoximine
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11292
  • cas:83730-53-4
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-12
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11292
用途 科研检测
英文名称 L-Buthionine Sulfoximine
包装规格 1MG
CAS编号 83730-53-4
别名 L-Buthionine Sulfoximine
纯度 98+%
分子式
是否进口
纯度:>98%,;NMR (Conforms)
分子式:C8H18N2O3S
分子量:222.31
溶剂:Water (5 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):GCL inhibitor
Function / Pharmacology:Buthionine sulfoximine is an irreversible inhibitor of γ-glutamylcysteine ligase (GCL). GCL is the first enzyme of the cellular glutathione biosynthetic pathway. Dysregulation of glutathione homeostasis is involved in many diseases including cancer, diabetes, neurodegenerative disorders and HIV/AIDS.1 Most disease states involve decreased glutathione synthesis, however, in cancer, it is increased supporting cellular proliferation and protecting cancer cells. Pharmacological inhibition of GCL has been examined as a potential cancer treatment.2-4
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