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L-Buthionine Sulfoximine
- 英文名称:L-Buthionine Sulfoximine
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11292
- cas:83730-53-4
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-12
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11292 |
用途 | 科研检测 |
英文名称 | L-Buthionine Sulfoximine |
包装规格 | 1MG |
CAS编号 | 83730-53-4 |
别名 | L-Buthionine Sulfoximine |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98%,;NMR (Conforms)
分子式:C8H18N2O3S
分子量:222.31
溶剂:Water (5 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):GCL inhibitor
Function / Pharmacology:Buthionine sulfoximine is an irreversible inhibitor of γ-glutamylcysteine ligase (GCL). GCL is the first enzyme of the cellular glutathione biosynthetic pathway. Dysregulation of glutathione homeostasis is involved in many diseases including cancer, diabetes, neurodegenerative disorders and HIV/AIDS.1 Most disease states involve decreased glutathione synthesis, however, in cancer, it is increased supporting cellular proliferation and protecting cancer cells. Pharmacological inhibition of GCL has been examined as a potential cancer treatment.2-4
分子式:C8H18N2O3S
分子量:222.31
溶剂:Water (5 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):GCL inhibitor
Function / Pharmacology:Buthionine sulfoximine is an irreversible inhibitor of γ-glutamylcysteine ligase (GCL). GCL is the first enzyme of the cellular glutathione biosynthetic pathway. Dysregulation of glutathione homeostasis is involved in many diseases including cancer, diabetes, neurodegenerative disorders and HIV/AIDS.1 Most disease states involve decreased glutathione synthesis, however, in cancer, it is increased supporting cellular proliferation and protecting cancer cells. Pharmacological inhibition of GCL has been examined as a potential cancer treatment.2-4