纯度:>98%,;NMR (Conforms)
分子式:C8H18N2O3S
分子量:222.31
溶剂:Water (5 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):GCL inhibitor
Function / Pharmacology:Buthionine sulfoximine is an irreversible inhibitor of γ-glutamylcysteine ligase (GCL). GCL is the first enzyme of the cellular glutathione biosynthetic pathway. Dysregulation of glutathione homeostasis is involved in many diseases including cancer, diabetes, neurodegenerative disorders and HIV/AIDS.1 Most disease states involve decreased glutathione synthesis, however, in cancer, it is increased supporting cellular proliferation and protecting cancer cells. Pharmacological inhibition of GCL has been examined as a potential cancer treatment.2-4