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FSG67
- 英文名称:FSG67
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11294
- cas:1158383-34-6
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11294 |
用途 | 科研检测 |
英文名称 | FSG67 |
包装规格 | 1MG |
CAS编号 | 1158383-34-6 |
别名 | FSG67 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C16H25NO4S
分子量:327.44
溶剂:DMSO (>25 mg/ml) Ethanol (>25 mg/ml)
性状:White solid
存储:RT
Activity (short version):GPAT inhibitor
Function / Pharmacology:FSG67 is an inhibitor of Glycerol 3-Phosphate Acyltransferase (GPAT); IC50 = 24 μM.1 It was able to reduce food intake, decrease body weight and adiposity, enhance energy utilization as fatty acid oxidation, reverse hepatic steatosis, and enhance insulin sensitivity in diet-induced obese mice while showing no in vitro or in vivo toxicity.2 FSG67 also caused decreased gene expression for orexigenic hypothalamic neuropeptides AgRP and NPY.2 FSG67 increased FAOx in primary hypothalamic neurons (PHN) leading to an increase in ATP and inactivation of AMPK. Oxidative stress and indicators of ER stress were also reduced in PHN.3
分子式:C16H25NO4S
分子量:327.44
溶剂:DMSO (>25 mg/ml) Ethanol (>25 mg/ml)
性状:White solid
存储:RT
Activity (short version):GPAT inhibitor
Function / Pharmacology:FSG67 is an inhibitor of Glycerol 3-Phosphate Acyltransferase (GPAT); IC50 = 24 μM.1 It was able to reduce food intake, decrease body weight and adiposity, enhance energy utilization as fatty acid oxidation, reverse hepatic steatosis, and enhance insulin sensitivity in diet-induced obese mice while showing no in vitro or in vivo toxicity.2 FSG67 also caused decreased gene expression for orexigenic hypothalamic neuropeptides AgRP and NPY.2 FSG67 increased FAOx in primary hypothalamic neurons (PHN) leading to an increase in ATP and inactivation of AMPK. Oxidative stress and indicators of ER stress were also reduced in PHN.3