纯度:99% by HPLC,;NMR (Conforms)
分子式:C17H12N2O
分子量:260.29
溶剂:DMSO (15 mg/ml) Ethanol (5 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):Phosphofructo-2-kinase (PFKFB3) inhibitor
Function / Pharmacology:PFK15 is an inhibitor of the metabolic enzyme 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3). PFKFB3 is constitutively expressed by neoplastic cells and is required for the high glycolytic rate (Warburg Effect) of these cells. PFK15 inhibits PFKFB3 (IC50 = 207 nM) without inhibiting 96 other kinases.1 PFK15 was able to potently inhibit glucose and F26BP uptake. It induced apoptosis and reduced tumor growth in vitro and in vivo. PFK15 has been shown to inhibit tumor growth in various cancer models.2,3