纯度:98% by TLC,;NMR (Conforms)
分子式:C20H13FO6
分子量:368.31
溶剂:DMSO (>25 mg/ml) Ethanol (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Glucose transport inhibitor
Function / Pharmacology:WZB117 is an inhibitor of Glucose Transporter 1 (GLUT1). It inhibited cell proliferation in lung cancer A549 cells and breast cancer MCF7 cells with an IC50 of approximately 10 μM. Daily intraperitoneal injection of WZB117 at 10mg/kg resulted in 70% reduction in tumor volume of human A549 lung cancer grafted on nude mice