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R162
- 英文名称:R162
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11307
- cas:64302-87-0
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11307 |
用途 | 科研检测 |
英文名称 | R162 |
包装规格 | 1MG |
CAS编号 | 64302-87-0 |
别名 | R162 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C17H12O3
分子量:264.28
溶剂:DMSO (10 mg/ml) Ethanol (5 mg/ml)
性状:Orange solid
存储:-20°C
Activity (short version):Glutamate Dehydrogenase 1 inhibitor
Function / Pharmacology:R162 (64302-87-0) is a selective inhibitor of glutamate dehydrogenase 1 (GDH1), a commonly upregulated enzyme in human cancers (Ki = 28.6 μM). It does not inhibit the activity of other NADPH enzymes such as 6-phosphogluconate dehydrogenase and fumarate hydratase. R162 treatment lead to decreased fumarate levels, lower glutathione peroxidase activity, increased ROS levels and reduced cell proliferation in H1299 and MDA-MB231 cells. R162 sensitizes LKB-1 deficient tumor cells to anoikis induction. R162 treatment (at 20 mg/kg/day) significantly attenuates metastatic potential in a xenograft mouse model.2 GDH1 is a promising antimetastasis target and R162 us a useful tool for proof of principal studies.
分子式:C17H12O3
分子量:264.28
溶剂:DMSO (10 mg/ml) Ethanol (5 mg/ml)
性状:Orange solid
存储:-20°C
Activity (short version):Glutamate Dehydrogenase 1 inhibitor
Function / Pharmacology:R162 (64302-87-0) is a selective inhibitor of glutamate dehydrogenase 1 (GDH1), a commonly upregulated enzyme in human cancers (Ki = 28.6 μM). It does not inhibit the activity of other NADPH enzymes such as 6-phosphogluconate dehydrogenase and fumarate hydratase. R162 treatment lead to decreased fumarate levels, lower glutathione peroxidase activity, increased ROS levels and reduced cell proliferation in H1299 and MDA-MB231 cells. R162 sensitizes LKB-1 deficient tumor cells to anoikis induction. R162 treatment (at 20 mg/kg/day) significantly attenuates metastatic potential in a xenograft mouse model.2 GDH1 is a promising antimetastasis target and R162 us a useful tool for proof of principal studies.