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Wnt-C59
- 英文名称：Wnt-C59
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11309
- cas：1243243-89-1
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-10-28
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11309 |
| 用途 | 科研检测 |
| 英文名称 | Wnt-C59 |
| 包装规格 | 1MG |
| CAS编号 | 1243243-89-1 |
| 别名 | Wnt-C59 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C25H21N3O
分子量:379.46
溶剂:DMSO (7 mg/ml) Ethanol (6 mg/ml).
性状:Tan Solid
存储:-20°C
Activity (short version):Porcupine inhibitor
Function / Pharmacology:Wnt-C59 is a potent (IC50 = 74 pmol/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase. Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms. It was able to block progression of mammary tumors in MMTV-WNT1 transgenic mice.1 Wnt-C59 strongly inhibited the growth of intestinal neoplasia in RZ-mutant mice. Wnt-C59 was able to efficiently differentiate pluripotent stem cells into cortical neurons (CTIP2+/COUP-TF1). Wnt-C59 was also able to dramatically attenuate kidney fibrosis via inhibition of collagen mRNA expression and expression of inflammatory cytokines.
分子式:C25H21N3O
分子量:379.46
溶剂:DMSO (7 mg/ml) Ethanol (6 mg/ml).
性状:Tan Solid
存储:-20°C
Activity (short version):Porcupine inhibitor
Function / Pharmacology:Wnt-C59 is a potent (IC50 = 74 pmol/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase. Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms. It was able to block progression of mammary tumors in MMTV-WNT1 transgenic mice.1 Wnt-C59 strongly inhibited the growth of intestinal neoplasia in RZ-mutant mice. Wnt-C59 was able to efficiently differentiate pluripotent stem cells into cortical neurons (CTIP2+/COUP-TF1). Wnt-C59 was also able to dramatically attenuate kidney fibrosis via inhibition of collagen mRNA expression and expression of inflammatory cytokines.
