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3PO
  • 英文名称:3PO
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11313
  • cas:18550-98-6
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-23
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11313
用途 科研检测
英文名称 3PO
包装规格 1MG
CAS编号 18550-98-6
别名 3PO
纯度 98+%
分子式
是否进口
纯度:99% by HPLC,;NMR (Conforms)
分子式:C13H10N2O
分子量:210.23
溶剂:DMSO (15 mg/ml) Ethanol (5 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):6-Phosphofructo-2-kinase (PFKFB3) inhibitor
Function / Pharmacology:3PO is an inhibitor of the metabolic enzyme 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3). PFKFB3 is constitutively expressed by neoplastic cells and is required for the high glycolytic rate (Warburg Effect) of these cells. 3PO inhibits PFKFB3 (IC50 = 1.4 – 24 μM for various cancer cell lines), suppresses glucose uptake, and lowers intracellular concentrations of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.1 Inhibition of cancer cell metabolism via blocking the action of PFKFB3 has been studied in various models.2-4 Inhibition of PFKFB3 has been shown to induce autophagy as a survival mechanism in cancer cells.5 3PO has also been used to reduce pathological angiogenesis.6
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