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FPS-ZM1
  • 英文名称:FPS-ZM1
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11319
  • cas:945714-67-0
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-12
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11319
用途 科研检测
英文名称 FPS-ZM1
包装规格 1MG
CAS编号 945714-67-0
别名 FPS-ZM1
纯度 98+%
分子式
是否进口
纯度:98% by HPLC,;NMR (Conforms)
分子式:C20H22ClNO
分子量:327.85
溶剂:DMSO (35 mg/ml) Ethanol (20 mg/ml)
性状:Off-White solid
存储:-20°C
Activity (short version):RAGE inhibitor
Function / Pharmacology:FPS-ZM1 is a high-affinity Receptor for Advanced Glycation End products (RAGE) inhibitor (IC50 = 0.6 μM). It is able to lower levels of Aβ via binding to the V domain of RAGE and can block multiple mechanisms of Aβ40- and Aβ42-induced cellular stress in RAGE-expressing brain endothelium, neurons and microglia in vitro and in vivo.1,2 Can cross the BBB. In a rat model of intracerebral hemorrhage, FPS-ZM1 was able to attenuate blood-brain barrier and white matter fiber damage.3 FPS-ZM1 inhibition of RAGE was able to ameliorate inflammatory damage after acute intracerebral hemorrhage via downstream blockade of high mobility box-1(HMGB1) signaling.4 FPS-ZM1 has also been shown to impair breast cancer cell invasion and metastasis.5
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