纯度:98% by HPLC;NMR (Conforms)
分子式:C20H20N2O2
分子量:320.39
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):SERCA activator
Function / Pharmacology:Allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA).1,2 It lowered fasting glucose levels, improved glucose tolerance, and ameliorated hepatitis steatosis in ob/ob mice.1 CDN1163 also rescued neurons from ER-stress-induced cell death in vitro and displayed significant efficacy in a rat 6-hydroxydopamine (6-OHDA) model of Parkinson’s disease.2 It reduced age-related muscle atrophy and weakness in a C57BL/6J mice.3 CDN1163 decreased inflammatory cytokines and chemokines and attenuated mitochondrial dysfunction in Influenza A infected H1395 cells.4