纯度:99% by HPLC,;NMR (Conforms)
分子式:C12H9N3O5S
分子量:307.28
溶剂:DMSO (>50 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Antiviral and antiparasitic agent
Function / Pharmacology:Nitazoxanide is a clinically relevant antiparasitic agent.1It has since been repurposed as a broad-spectrum antiviral agent that is active against many RNA and DNA viruses including influenza, Hepatitis B and C, RSV, coronavirus, dengue and others.2 Its antiparasitic activity is believed to be due to inhibition of pyruvate:ferredoxin/flavodoxin oxidoreductases.3 Antiviral activity involves activation of protein kinase activated by double-stranded RNA (PKR) leading to phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α).4 Nitazoxanide has also been found to inhibit Wnt signaling independent of adenomatous polyposis coli (APC) – it targets peptidyl arginine deiminase 2 (PAD2) resulting in increased citrullination of β-catenin.5