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Nitisinone
- 英文名称：Nitisinone
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11336
- cas：104206-65-7
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-12-08
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11336 |
| 用途 | 科研检测 |
| 英文名称 | Nitisinone |
| 包装规格 | 1MG |
| CAS编号 | 104206-65-7 |
| 别名 | Nitisinone |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by TLC (NMR Conforms)
分子式:C14H10F3NO5
分子量:329.23
溶剂:DMSO (>10 mg/ml) Ethanol (10 mg/ml)
性状:Beige solid
存储:-20°C
Activity (short version):Tyrosine metabolism inhibitor
Function / Pharmacology:Inhibitor of 4-Hydroxyphenylpyruvate dioxygenase (HPPD; IC50 = 40 nM1 and 173 nM2) and is in clinical use for the treatment of hereditary tyrosinemia type 13. CD13+ cancer stem cells (CSCs) are dependent on aerobic metabolism of tyrosine - Nitisinone inhibition of tyrosine metabolism results in lowered availability of acetyl-CoA and fumarate for use in the citric acid cycle causing these CSCs to enter cell cycle, decreasing self-renewal, and making them more susceptible to chemotherapy.4 Nitisinone is a potential treatment option for cancers that rely on tyrosine metabolism.
分子式:C14H10F3NO5
分子量:329.23
溶剂:DMSO (>10 mg/ml) Ethanol (10 mg/ml)
性状:Beige solid
存储:-20°C
Activity (short version):Tyrosine metabolism inhibitor
Function / Pharmacology:Inhibitor of 4-Hydroxyphenylpyruvate dioxygenase (HPPD; IC50 = 40 nM1 and 173 nM2) and is in clinical use for the treatment of hereditary tyrosinemia type 13. CD13+ cancer stem cells (CSCs) are dependent on aerobic metabolism of tyrosine - Nitisinone inhibition of tyrosine metabolism results in lowered availability of acetyl-CoA and fumarate for use in the citric acid cycle causing these CSCs to enter cell cycle, decreasing self-renewal, and making them more susceptible to chemotherapy.4 Nitisinone is a potential treatment option for cancers that rely on tyrosine metabolism.
