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Nitisinone
- 英文名称:Nitisinone
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11336
- cas:104206-65-7
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11336 |
用途 | 科研检测 |
英文名称 | Nitisinone |
包装规格 | 1MG |
CAS编号 | 104206-65-7 |
别名 | Nitisinone |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98% by TLC (NMR Conforms)
分子式:C14H10F3NO5
分子量:329.23
溶剂:DMSO (>10 mg/ml) Ethanol (10 mg/ml)
性状:Beige solid
存储:-20°C
Activity (short version):Tyrosine metabolism inhibitor
Function / Pharmacology:Inhibitor of 4-Hydroxyphenylpyruvate dioxygenase (HPPD; IC50 = 40 nM1 and 173 nM2) and is in clinical use for the treatment of hereditary tyrosinemia type 13. CD13+ cancer stem cells (CSCs) are dependent on aerobic metabolism of tyrosine - Nitisinone inhibition of tyrosine metabolism results in lowered availability of acetyl-CoA and fumarate for use in the citric acid cycle causing these CSCs to enter cell cycle, decreasing self-renewal, and making them more susceptible to chemotherapy.4 Nitisinone is a potential treatment option for cancers that rely on tyrosine metabolism.
分子式:C14H10F3NO5
分子量:329.23
溶剂:DMSO (>10 mg/ml) Ethanol (10 mg/ml)
性状:Beige solid
存储:-20°C
Activity (short version):Tyrosine metabolism inhibitor
Function / Pharmacology:Inhibitor of 4-Hydroxyphenylpyruvate dioxygenase (HPPD; IC50 = 40 nM1 and 173 nM2) and is in clinical use for the treatment of hereditary tyrosinemia type 13. CD13+ cancer stem cells (CSCs) are dependent on aerobic metabolism of tyrosine - Nitisinone inhibition of tyrosine metabolism results in lowered availability of acetyl-CoA and fumarate for use in the citric acid cycle causing these CSCs to enter cell cycle, decreasing self-renewal, and making them more susceptible to chemotherapy.4 Nitisinone is a potential treatment option for cancers that rely on tyrosine metabolism.