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P505-15
- 英文名称:P505-15
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11337
- cas:1370261-97-4
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-12
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11337 |
用途 | 科研检测 |
英文名称 | P505-15 |
包装规格 | 1MG |
CAS编号 | 1370261-97-4 |
别名 | P505-15 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C19H23N9O·HCl
分子量:429.91
溶剂:DMSO (25 mg/mL); Water (>25 mg/mL)
性状:White solid
存储:-20°C
Activity (short version):Highly selective Syk inhibitor
Function / Pharmacology:P505-15 is a highly selective and potent (IC50 = 1-2 nM) inhibitor of spleen tyrosine kinase (Syk).1 It potently inhibited B cell antigen receptor-mediated B cell signaling/activation and basophil degranulation. It displayed anti-inflammatory activity in rodent models of rheumatoid arthritis. P505-15 displayed efficacy in vitro and in vivo in non-Hodgkin lymphoma and chronic lymphocytic leukemia models.2,3 It protected against toxin-induced hepatic fibrosis, associated hepatocellular injury, and hepatocarcinogenesis.4 P505-15 was also found to inhibit PINK1 (IC50 = 0.5-3 μM) in HeLa cells and dopaminergic neurons.5
分子式:C19H23N9O·HCl
分子量:429.91
溶剂:DMSO (25 mg/mL); Water (>25 mg/mL)
性状:White solid
存储:-20°C
Activity (short version):Highly selective Syk inhibitor
Function / Pharmacology:P505-15 is a highly selective and potent (IC50 = 1-2 nM) inhibitor of spleen tyrosine kinase (Syk).1 It potently inhibited B cell antigen receptor-mediated B cell signaling/activation and basophil degranulation. It displayed anti-inflammatory activity in rodent models of rheumatoid arthritis. P505-15 displayed efficacy in vitro and in vivo in non-Hodgkin lymphoma and chronic lymphocytic leukemia models.2,3 It protected against toxin-induced hepatic fibrosis, associated hepatocellular injury, and hepatocarcinogenesis.4 P505-15 was also found to inhibit PINK1 (IC50 = 0.5-3 μM) in HeLa cells and dopaminergic neurons.5