纯度:>98% by HPLC;NMR (Conforms)
分子式:C19H23N9O·HCl
分子量:429.91
溶剂:DMSO (25 mg/mL); Water (>25 mg/mL)
性状:White solid
存储:-20°C
Activity (short version):Highly selective Syk inhibitor
Function / Pharmacology:P505-15 is a highly selective and potent (IC50 = 1-2 nM) inhibitor of spleen tyrosine kinase (Syk).1 It potently inhibited B cell antigen receptor-mediated B cell signaling/activation and basophil degranulation. It displayed anti-inflammatory activity in rodent models of rheumatoid arthritis. P505-15 displayed efficacy in vitro and in vivo in non-Hodgkin lymphoma and chronic lymphocytic leukemia models.2,3 It protected against toxin-induced hepatic fibrosis, associated hepatocellular injury, and hepatocarcinogenesis.4 P505-15 was also found to inhibit PINK1 (IC50 = 0.5-3 μM) in HeLa cells and dopaminergic neurons.5