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VU0134992
- 英文名称:VU0134992
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11338
- cas:755002-90-5
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11338 |
用途 | 科研检测 |
英文名称 | VU0134992 |
包装规格 | 1MG |
CAS编号 | 755002-90-5 |
别名 | VU0134992 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC;NMR (Conforms)
分子式:C20H31BrN2O2
分子量:411.38
溶剂:DMSO (>25 mg/ml)
性状:Off-white/tan solid
存储:-20°C
Activity (short version):Kir4.1 blocker
Function / Pharmacology:VU0134992 is a blocker of the inward rectifier potassium channel Kir4.1 (IC50 = 970 nM).1 It also inhibits Kir3.1/3.2, Kir3.1/3.4, and Kir4.2 with similar potency. VU0134992 induced diuresis, natriuresis, and kaliuresis in Sprague-Dawley rats suggesting therapeutic blood pressure lowering potential. It reduced polymyxin-induced nephrotoxicity in cell culture and mouse explant kidney tissue.2
分子式:C20H31BrN2O2
分子量:411.38
溶剂:DMSO (>25 mg/ml)
性状:Off-white/tan solid
存储:-20°C
Activity (short version):Kir4.1 blocker
Function / Pharmacology:VU0134992 is a blocker of the inward rectifier potassium channel Kir4.1 (IC50 = 970 nM).1 It also inhibits Kir3.1/3.2, Kir3.1/3.4, and Kir4.2 with similar potency. VU0134992 induced diuresis, natriuresis, and kaliuresis in Sprague-Dawley rats suggesting therapeutic blood pressure lowering potential. It reduced polymyxin-induced nephrotoxicity in cell culture and mouse explant kidney tissue.2