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VU0134992
- 英文名称：VU0134992
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11338
- cas：755002-90-5
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-16
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11338 |
| 用途 | 科研检测 |
| 英文名称 | VU0134992 |
| 包装规格 | 1MG |
| CAS编号 | 755002-90-5 |
| 别名 | VU0134992 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by TLC;NMR (Conforms)
分子式:C20H31BrN2O2
分子量:411.38
溶剂:DMSO (>25 mg/ml)
性状:Off-white/tan solid
存储:-20°C
Activity (short version):Kir4.1 blocker
Function / Pharmacology:VU0134992 is a blocker of the inward rectifier potassium channel Kir4.1 (IC50 = 970 nM).1 It also inhibits Kir3.1/3.2, Kir3.1/3.4, and Kir4.2 with similar potency. VU0134992 induced diuresis, natriuresis, and kaliuresis in Sprague-Dawley rats suggesting therapeutic blood pressure lowering potential. It reduced polymyxin-induced nephrotoxicity in cell culture and mouse explant kidney tissue.2
分子式:C20H31BrN2O2
分子量:411.38
溶剂:DMSO (>25 mg/ml)
性状:Off-white/tan solid
存储:-20°C
Activity (short version):Kir4.1 blocker
Function / Pharmacology:VU0134992 is a blocker of the inward rectifier potassium channel Kir4.1 (IC50 = 970 nM).1 It also inhibits Kir3.1/3.2, Kir3.1/3.4, and Kir4.2 with similar potency. VU0134992 induced diuresis, natriuresis, and kaliuresis in Sprague-Dawley rats suggesting therapeutic blood pressure lowering potential. It reduced polymyxin-induced nephrotoxicity in cell culture and mouse explant kidney tissue.2
