|
ML365
- 英文名称：ML365
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11344
- cas：947914-18-3
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-07-12
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11344 |
| 用途 | 科研检测 |
| 英文名称 | ML365 |
| 包装规格 | 1MG |
| CAS编号 | 947914-18-3 |
| 别名 | ML365 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C22H20N2O3
分子量:360.41
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Potent and selective K2P3.1 blocker
Function / Pharmacology:ML365 is a potent (IC50 = 16 nM) and selective (62-fold selective over TASK-3) blocker of the two-pore domain potassium channel K2P3.1 (TASK-1) .1 It also less potently (IC50 = 4.07 μM) blocks the K2P6.1 (TWIK-2) channel resulting in blocking the ATP-induced NLRP3 inflammasome.2 ML365 improved the efficacy of Levetiracetam in chronically epileptic rats.3 It suppressed the release of TNF-α, IL-6, and IL-1? in an LPS-induced inflammatory model via regulation of NF-kB signaling.4
分子式:C22H20N2O3
分子量:360.41
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Potent and selective K2P3.1 blocker
Function / Pharmacology:ML365 is a potent (IC50 = 16 nM) and selective (62-fold selective over TASK-3) blocker of the two-pore domain potassium channel K2P3.1 (TASK-1) .1 It also less potently (IC50 = 4.07 μM) blocks the K2P6.1 (TWIK-2) channel resulting in blocking the ATP-induced NLRP3 inflammasome.2 ML365 improved the efficacy of Levetiracetam in chronically epileptic rats.3 It suppressed the release of TNF-α, IL-6, and IL-1? in an LPS-induced inflammatory model via regulation of NF-kB signaling.4
