纯度:>98% by HPLC;NMR (Conforms)
分子式:C14H13ClF6N6
分子量:414.74
溶剂:DMSO (25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Isocitrate dehydrogenase (IDH) 1/2 inhibitor
Function / Pharmacology:Vorasidenib is a highly potent (IC50’s = 7 nM IDH2-R140Q, 0.6 nM IDH1-R132H/WT, and 0.25 nM Neurosphere TS603 IDH1-R132H), selective, and brain-penetrant inhibitor of mutant isocitrate dehydrogenase 1 and 2 (IDH1/2).1 It led to >97% inhibition of 2-hydroxyglutarate production in mIDH1 glioma tissue. Vorasidenib significantly improved progression-free survival and delayed time to next intervention in a phase 3 glioma trial.2