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Lomitapide
- 英文名称：Lomitapide
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11349
- cas：182431-12-5
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11349 |
| 用途 | 科研检测 |
| 英文名称 | Lomitapide |
| 包装规格 | 1MG |
| CAS编号 | 182431-12-5 |
| 别名 | Lomitapide |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C39H37F6N3O2
分子量:693.73
溶剂:DMSO (50 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Microsomal triglyceride transfer protein inhibitor
Function / Pharmacology:Lomitapide is a potent (IC50 = 8 nM) inhibitor of microsomal triglyceride transfer protein (MTP or MTTP) and is clinically useful in treating familial hypercholesterolemia.1,2 It has displayed anticancer activity acting through various pathways including autophagy-dependent cancer cell death via direct inhibition of the kinase activity of mTORC13, activation of AMPK/Beclin1-mediated autophagy4, Notch inhibition via targeting TACE and γ-secretase5, blocking ZDHHC5-dependent palmitoylation on SSTR56, PFKFB3 inhibition7, and PARP14/DRP1-mediated mitophagy8.
分子式:C39H37F6N3O2
分子量:693.73
溶剂:DMSO (50 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Microsomal triglyceride transfer protein inhibitor
Function / Pharmacology:Lomitapide is a potent (IC50 = 8 nM) inhibitor of microsomal triglyceride transfer protein (MTP or MTTP) and is clinically useful in treating familial hypercholesterolemia.1,2 It has displayed anticancer activity acting through various pathways including autophagy-dependent cancer cell death via direct inhibition of the kinase activity of mTORC13, activation of AMPK/Beclin1-mediated autophagy4, Notch inhibition via targeting TACE and γ-secretase5, blocking ZDHHC5-dependent palmitoylation on SSTR56, PFKFB3 inhibition7, and PARP14/DRP1-mediated mitophagy8.
