纯度:98% by HPLC;NMR (Conforms)
分子式:C25H31N3O5S2
分子量:517.66
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Squalene synthase activator / GPX4 degradation
Function / Pharmacology:FIN56 is a novel inducer of ferroptosis acting via degradation of GPX4 and activation of squalene synthase (leading to CoQ10 depletion, a compound which inhibits ferroptosis via an unknown mechanism).1 FIN56 inhibited glioblastoma growth in vitro and in vivo via induction of ferroptosis as well as lysosomal membrane permeabilization.2