纯度:>99% by HPLC;NMR (Conforms)
分子式:C26H31N3O5
分子量:465.54
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):HSP90 inhibitor
Function / Pharmacology:Luminespib is a potent inhibitor (IC50 = 21 nM) of HSP90.1 It is active against various human tumor xenograft models acting via several processes including cytostasis, apoptosis, invasion, and angiogenesis.2,3 Luminespib enhances tumor susceptibility to T-cell-based immunotherapy by re-invigorating the cancer-immunity cycle in NANOG+ cancer cells.4 It also acts as a radiosensitizer against various tumor cells.5-7