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Dubermatinib
- 英文名称：Dubermatinib
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11359
- cas：1341200-45-0
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11359 |
| 用途 | 科研检测 |
| 英文名称 | Dubermatinib |
| 包装规格 | 1MG |
| CAS编号 | 1341200-45-0 |
| 别名 | Dubermatinib |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C24H30ClN7O2S
分子量:516.06
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):AXL inhibitor
Function / Pharmacology:Potent (IC50 = 27 nM) inhibitor of the TAM family kinase AXL.1 It displayed potent activity against the pancreatic tumor cell line PSN-1 (IC50 = 6 nM). Dubermatinib also strongly inhibited the kinases Aurora A/B, JAK2, ABL1, and CHEK1. It induced apoptosis in chronic lymphocytic leukemia (CLL) cells and acted synergistically with BTK inhibitors against CLL cells.2 It inhibited neuroblastoma cell growth and enhanced sensitivity to conventional chemotherapy.3 Dubermatinib was also active in a drug-resistant acute myeloid leukemia model4 and reduced metastasis and therapy resistance in pancreatic cancer models5.
分子式:C24H30ClN7O2S
分子量:516.06
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):AXL inhibitor
Function / Pharmacology:Potent (IC50 = 27 nM) inhibitor of the TAM family kinase AXL.1 It displayed potent activity against the pancreatic tumor cell line PSN-1 (IC50 = 6 nM). Dubermatinib also strongly inhibited the kinases Aurora A/B, JAK2, ABL1, and CHEK1. It induced apoptosis in chronic lymphocytic leukemia (CLL) cells and acted synergistically with BTK inhibitors against CLL cells.2 It inhibited neuroblastoma cell growth and enhanced sensitivity to conventional chemotherapy.3 Dubermatinib was also active in a drug-resistant acute myeloid leukemia model4 and reduced metastasis and therapy resistance in pancreatic cancer models5.
