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Necrostatin-34
- 英文名称：Necrostatin-34
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11362
- cas：375835-43-1
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11362 |
| 用途 | 科研检测 |
| 英文名称 | Necrostatin-34 |
| 包装规格 | 1MG |
| CAS编号 | 375835-43-1 |
| 别名 | Necrostatin-34 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C18H16N4O2S2
分子量:384.47
溶剂:DMSO (>25 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):RIP1 kinase inhibitor
Function / Pharmacology:Necrostatin-34 is a selective inhibitor of RIP1 kinase. IC50s = 667 nM and 134 nM for TNFα in FAD-deficient Jurkat cells and L929 cells respectively. It binds to a site distinct from that of 7-Cl-O-Nec1 (Focus Cat# 10-4544) locking the enzyme in an inactive conformation. Necrostatin-34 acts synergistically with 7-Cl-O-Nec1 to inhibit necroptosis.
分子式:C18H16N4O2S2
分子量:384.47
溶剂:DMSO (>25 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):RIP1 kinase inhibitor
Function / Pharmacology:Necrostatin-34 is a selective inhibitor of RIP1 kinase. IC50s = 667 nM and 134 nM for TNFα in FAD-deficient Jurkat cells and L929 cells respectively. It binds to a site distinct from that of 7-Cl-O-Nec1 (Focus Cat# 10-4544) locking the enzyme in an inactive conformation. Necrostatin-34 acts synergistically with 7-Cl-O-Nec1 to inhibit necroptosis.
