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JH-X-119-01
- 英文名称：JH-X-119-01
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11367
- cas：2227368-54-7
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11367 |
| 用途 | 科研检测 |
| 英文名称 | JH-X-119-01 |
| 包装规格 | 1MG |
| CAS编号 | 2227368-54-7 |
| 别名 | JH-X-119-01 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C25H20N6O3
分子量:452.47
溶剂:DMSO (>25 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Selective IRAK1 inhibitor
Function / Pharmacology:JH-X-119-01 is a highly selective (significantly inhibited only YSK4 and MEK3 in a panel of over 300 kinases) and potent (IC50 = 9 nM) covalent inhibitor of interleukin 1 receptor-associated kinase 1 (IRAK1). It displayed cytotoxic activity against several lymphoma cell lines and exhibited synergism with the BTK inhibitor Ibrutinib in the same systems. JH-X-119-01 protected mice from LPS-induced sepsis2 and ameliorated acute graft-versus-host disease in mice undergoing allogenic hematopoietic cell transplantation without effecting the anti-lymphoma effect3.
分子式:C25H20N6O3
分子量:452.47
溶剂:DMSO (>25 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Selective IRAK1 inhibitor
Function / Pharmacology:JH-X-119-01 is a highly selective (significantly inhibited only YSK4 and MEK3 in a panel of over 300 kinases) and potent (IC50 = 9 nM) covalent inhibitor of interleukin 1 receptor-associated kinase 1 (IRAK1). It displayed cytotoxic activity against several lymphoma cell lines and exhibited synergism with the BTK inhibitor Ibrutinib in the same systems. JH-X-119-01 protected mice from LPS-induced sepsis2 and ameliorated acute graft-versus-host disease in mice undergoing allogenic hematopoietic cell transplantation without effecting the anti-lymphoma effect3.
