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GSK8612
- 英文名称：GSK8612
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11369
- cas：2361659-62-1
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11369 |
| 用途 | 科研检测 |
| 英文名称 | GSK8612 |
| 包装规格 | 1MG |
| CAS编号 | 2361659-62-1 |
| 别名 | GSK8612 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C17H17BrF3N7O2S
分子量:520.33
溶剂:Soluble in DMSO (20 mg/ml)
性状:Beige solid
存储:-20°C
Activity (short version):Highly selective TBK1 inhibitor
Function / Pharmacology:Highly selective and potent (avg. pIC50 = 6.8 versus recombinant TBK1) inhibitor of Tank-binding Kinase-1 (TBK1) with higher affinity for unactivated TBK1. It inhibited phosphorylation of IRF3 (pIC50 = 6.0), inhibited the release of IFNa from human PBMC’s (pIC50 = 6.1), and inhibited IFNb secretion from THP-1 cells (pIC50 = 5.8 dsDNA virus, 6.3 cGAMP stilmulated cells).
分子式:C17H17BrF3N7O2S
分子量:520.33
溶剂:Soluble in DMSO (20 mg/ml)
性状:Beige solid
存储:-20°C
Activity (short version):Highly selective TBK1 inhibitor
Function / Pharmacology:Highly selective and potent (avg. pIC50 = 6.8 versus recombinant TBK1) inhibitor of Tank-binding Kinase-1 (TBK1) with higher affinity for unactivated TBK1. It inhibited phosphorylation of IRF3 (pIC50 = 6.0), inhibited the release of IFNa from human PBMC’s (pIC50 = 6.1), and inhibited IFNb secretion from THP-1 cells (pIC50 = 5.8 dsDNA virus, 6.3 cGAMP stilmulated cells).
