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NVP-231
- 英文名称：NVP-231
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11370
- cas：362003-83-6
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-16
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11370 |
| 用途 | 科研检测 |
| 英文名称 | NVP-231 |
| 包装规格 | 1MG |
| CAS编号 | 362003-83-6 |
| 别名 | NVP-231 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C25H25N3O3S
分子量:431.55
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Ceramide kinase inhibitor
Function / Pharmacology:Reversible inhibitor of ceramide kinase (IC50 = 12 nM).1 At 10 nM, it inhibited ceramide-1-phosphate formation by >50% and at 100 nM it completely inhibited its formation in cell culture. NVP-231 was inactive against hSphK1/2, hPI3Ka, hPI4Kb, hVps34, hGCS, hSMS-1, CERT, and 500-fold less potent against hDAGKa. NVP-231 inhibited breast and lung cancer cell proliferation via M phase arrest.2 It potently blocked cell migration and invasion in PANC-1 pancreatic cancer cells3 as well as MDA-MB-231 breast cancer cells4.
分子式:C25H25N3O3S
分子量:431.55
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Ceramide kinase inhibitor
Function / Pharmacology:Reversible inhibitor of ceramide kinase (IC50 = 12 nM).1 At 10 nM, it inhibited ceramide-1-phosphate formation by >50% and at 100 nM it completely inhibited its formation in cell culture. NVP-231 was inactive against hSphK1/2, hPI3Ka, hPI4Kb, hVps34, hGCS, hSMS-1, CERT, and 500-fold less potent against hDAGKa. NVP-231 inhibited breast and lung cancer cell proliferation via M phase arrest.2 It potently blocked cell migration and invasion in PANC-1 pancreatic cancer cells3 as well as MDA-MB-231 breast cancer cells4.
