纯度:>98% by HPLC;NMR (Conforms)
分子式:C5H4N4S·H2O
分子量:170.19
溶剂:DMSO (>50 mg/ml) Ethanol (5 mg/ml with warming)
性状:Yellow solid
存储:RT
Activity (short version):Purine antimetabolite and immunomodulator
Function / Pharmacology:Purine antimetabolite drug used to treat acute lymphocytic leukemia, Crohn’s disease, ulcerative colitis, and inflammatory bowel disease.1 It inhibits DNA synthesis by inhibiting the production of purine containing nucleotides. The immunomodulatory activity of 6-Mercaptopurine is mainly the result of the 6-MP metabolite 6-thioguanine triphosphate (6-TGTP) binding to small GTPase Rac1.2