纯度:98% by HPLC;NMR (Conforms)
分子式:C24H16F4N6O2
分子量:496.43
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):GLUT1 inhibitor
Function / Pharmacology:Potent inhibitor (IC50 = 2 nM) of the facilitative glucose transporter GLUT1, an enzyme frequently overexpressed in many cancers.1 It shows greater than 100-fold selectivity over GLUT2-4. BAY-876 displayed potent antitumor activity in ovarian cancer xenograft models2 and in triple negative breast cancer cells displaying high glycolytic and low oxidative phosphorylation rates3. It reduced CD4+ T cell proliferation and IFN-γ secretion via GLUT1 inhibition suggesting utility against auto-inflammatory diseases.4 BAY-876 induces disulfidptosis in SLCA11high cancer cells.5