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GSK2334470
- 英文名称：GSK2334470
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11380
- cas：1227911-45-6
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11380 |
| 用途 | 科研检测 |
| 英文名称 | GSK2334470 |
| 包装规格 | 1MG |
| CAS编号 | 1227911-45-6 |
| 别名 | GSK2334470 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C25H34N8O
分子量:462.6
溶剂:DMSO (> 25 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Potent and selective PDK1 inhibitor
Function / Pharmacology:Potent (IC50 = 10 nM) and selective inhibitor of 3-Phosphoinositide-dependent kinase 1 (PDK1), which phosphorylates and activates a group of protein kinases in the AGC/PKG/PKC family.1 It is more effective at inhibiting PDK1 substrates that are activated in the cytosol rather than at the plasma membrane.1 GSK2334470 delayed melanogenesis and metastasis in Braf(V600E)::Pten(-/-) mice.2 It also displays antitumor activity against multiple myeloma synergistically with mTORC1/2 inhibitor PP2423 and proteasome inhibitor MG-1324.
分子式:C25H34N8O
分子量:462.6
溶剂:DMSO (> 25 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Potent and selective PDK1 inhibitor
Function / Pharmacology:Potent (IC50 = 10 nM) and selective inhibitor of 3-Phosphoinositide-dependent kinase 1 (PDK1), which phosphorylates and activates a group of protein kinases in the AGC/PKG/PKC family.1 It is more effective at inhibiting PDK1 substrates that are activated in the cytosol rather than at the plasma membrane.1 GSK2334470 delayed melanogenesis and metastasis in Braf(V600E)::Pten(-/-) mice.2 It also displays antitumor activity against multiple myeloma synergistically with mTORC1/2 inhibitor PP2423 and proteasome inhibitor MG-1324.
