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CB-103
- 英文名称:CB-103
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11383
- cas:218457-67-1
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-12
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11383 |
用途 | 科研检测 |
英文名称 | CB-103 |
包装规格 | 1MG |
CAS编号 | 218457-67-1 |
别名 | CB-103 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC,;NMR (Conforms)
分子式:C15H18N2O
分子量:242.32
溶剂:DMSO (>30 mg/ml)
性状:Off-white to pale orange solid
存储:RT
Activity (short version):Notch signaling pathway inhibitor
Function / Pharmacology:Orally active inhibitor of the Notch signaling activation complex (IC50’s from 0.9 to 3.9 μM in various cell-based assays), the most downstream level of the Notch signaling pathway. It inhibited the growth of Notch-addicted human T cell acute lymphoblastic leukemia cells as well as other cell lines. CB-103 also inhibited the growth of human breast cancer and leukemia xenografts without the intestinal toxicity associated with γ-secretase Notch inhibitors.
分子式:C15H18N2O
分子量:242.32
溶剂:DMSO (>30 mg/ml)
性状:Off-white to pale orange solid
存储:RT
Activity (short version):Notch signaling pathway inhibitor
Function / Pharmacology:Orally active inhibitor of the Notch signaling activation complex (IC50’s from 0.9 to 3.9 μM in various cell-based assays), the most downstream level of the Notch signaling pathway. It inhibited the growth of Notch-addicted human T cell acute lymphoblastic leukemia cells as well as other cell lines. CB-103 also inhibited the growth of human breast cancer and leukemia xenografts without the intestinal toxicity associated with γ-secretase Notch inhibitors.