纯度:98% by TLC;NMR (Conforms)
分子式:C18H12N2O2
分子量:288.30
溶剂:DMSO (30 mg/ml) Ethanol (8 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Mitochondrial pyruvate transporter inhibitor
Function / Pharmacology:Potent inhibitor of the mitochondrial pyruvate carrier (MPC).1 Rapidly increases glucose uptake in human monocytes.2 Attenuates mitochondrial oxidative phosphorylation and increases glycolysis creating greater stem-like properties in LnCap prostate cancer cells.3 Blocks the neuroprotective action of L-lactate or pyruvate during glutamate-induced excitotoxicity.4 Inhibits pyruvate transport across the plasma membrane of trypanosomes (Ki=49 μM).5