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Deucravacitinib
- 英文名称:Deucravacitinib
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11388
- cas:1609392-27-9
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-16
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11388 |
用途 | 科研检测 |
英文名称 | Deucravacitinib |
包装规格 | 1MG |
CAS编号 | 1609392-27-9 |
别名 | Deucravacitinib |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C20H19D3N8O3
分子量:425.47
溶剂:DMSO (25 mg/ml with warming) Ethanol (20 mg/ml)
性状:White or off-white solid
存储:-20°C
Activity (short version):Allosteric TYK2 inhibitor
Function / Pharmacology:Deucravacitinib is very potent and selective allosteric inhibitor of tyrosine kinase 2 (TYK2). It binds to and is selective for the TYK2 pseudokinase domain (JH2, IC50 = 0.2 nM), with no activity against canonical JH1 domain of TYK2, JAK1,2, or 3.1 It is 5-fold less active against the JAK1 JH2 domain (IC50 = 1 nM). Deucravacitinib blocked signaling and functional responses in human TH17, TH1, B cells, and myeloid cells and displayed robust efficacy in vitro and in vivo in autoimmune disease animal models.2
分子式:C20H19D3N8O3
分子量:425.47
溶剂:DMSO (25 mg/ml with warming) Ethanol (20 mg/ml)
性状:White or off-white solid
存储:-20°C
Activity (short version):Allosteric TYK2 inhibitor
Function / Pharmacology:Deucravacitinib is very potent and selective allosteric inhibitor of tyrosine kinase 2 (TYK2). It binds to and is selective for the TYK2 pseudokinase domain (JH2, IC50 = 0.2 nM), with no activity against canonical JH1 domain of TYK2, JAK1,2, or 3.1 It is 5-fold less active against the JAK1 JH2 domain (IC50 = 1 nM). Deucravacitinib blocked signaling and functional responses in human TH17, TH1, B cells, and myeloid cells and displayed robust efficacy in vitro and in vivo in autoimmune disease animal models.2