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Deucravacitinib
  • 英文名称:Deucravacitinib
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11388
  • cas:1609392-27-9
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-23
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11388
用途 科研检测
英文名称 Deucravacitinib
包装规格 1MG
CAS编号 1609392-27-9
别名 Deucravacitinib
纯度 98+%
分子式
是否进口
纯度:98% by HPLC;NMR (Conforms)
分子式:C20H19D3N8O3
分子量:425.47
溶剂:DMSO (25 mg/ml with warming) Ethanol (20 mg/ml)
性状:White or off-white solid
存储:-20°C
Activity (short version):Allosteric TYK2 inhibitor
Function / Pharmacology:Deucravacitinib is very potent and selective allosteric inhibitor of tyrosine kinase 2 (TYK2). It binds to and is selective for the TYK2 pseudokinase domain (JH2, IC50 = 0.2 nM), with no activity against canonical JH1 domain of TYK2, JAK1,2, or 3.1 It is 5-fold less active against the JAK1 JH2 domain (IC50 = 1 nM). Deucravacitinib blocked signaling and functional responses in human TH17, TH1, B cells, and myeloid cells and displayed robust efficacy in vitro and in vivo in autoimmune disease animal models.2
联系方式
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