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Ibrutinib
- 英文名称:Ibrutinib
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11389
- cas:936563-96-1
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11389 |
用途 | 科研检测 |
英文名称 | Ibrutinib |
包装规格 | 1MG |
CAS编号 | 936563-96-1 |
别名 | Ibrutinib |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:99% by HPLC;NMR (Conforms)
分子式:C25H24N6O2
分子量:440.51
溶剂:DMSO (>25 mg/ml)
性状:White or off-white solid
存储:-20°C
Activity (short version):BTK inhibitor
Function / Pharmacology:Ibrutinib (936563-96-1) is a very potent (IC50 = 0.5nM) irreversible inhibitor of Bruton tyrosine kinase (BTK) that blocks activation of the B-cell antigen receptor (BCR).1 Ibrutinib also potently inhibits several other kinases including BLK, BMS, FGR, EGFR, and ITK. It is a clinically useful drug to treat B cell cancers. It inhibits CLL cell migration and survival2,3 and downregulates expression of CD204. It enhanced antitumor immune responses in combination with anti PD-L1 blockade via its inhibition of ITK (IL2-inducible T-cell kinase).5
分子式:C25H24N6O2
分子量:440.51
溶剂:DMSO (>25 mg/ml)
性状:White or off-white solid
存储:-20°C
Activity (short version):BTK inhibitor
Function / Pharmacology:Ibrutinib (936563-96-1) is a very potent (IC50 = 0.5nM) irreversible inhibitor of Bruton tyrosine kinase (BTK) that blocks activation of the B-cell antigen receptor (BCR).1 Ibrutinib also potently inhibits several other kinases including BLK, BMS, FGR, EGFR, and ITK. It is a clinically useful drug to treat B cell cancers. It inhibits CLL cell migration and survival2,3 and downregulates expression of CD204. It enhanced antitumor immune responses in combination with anti PD-L1 blockade via its inhibition of ITK (IL2-inducible T-cell kinase).5