纯度:99% by HPLC;NMR (Conforms)
分子式:C25H24N6O2
分子量:440.51
溶剂:DMSO (>25 mg/ml)
性状:White or off-white solid
存储:-20°C
Activity (short version):BTK inhibitor
Function / Pharmacology:Ibrutinib (936563-96-1) is a very potent (IC50 = 0.5nM) irreversible inhibitor of Bruton tyrosine kinase (BTK) that blocks activation of the B-cell antigen receptor (BCR).1 Ibrutinib also potently inhibits several other kinases including BLK, BMS, FGR, EGFR, and ITK. It is a clinically useful drug to treat B cell cancers. It inhibits CLL cell migration and survival2,3 and downregulates expression of CD204. It enhanced antitumor immune responses in combination with anti PD-L1 blockade via its inhibition of ITK (IL2-inducible T-cell kinase).5