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Trametinib
- 英文名称:Trametinib
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11390
- cas:871700-17-3
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-06-16
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11390 |
用途 | 科研检测 |
英文名称 | Trametinib |
包装规格 | 1MG |
CAS编号 | 871700-17-3 |
别名 | Trametinib |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC/HPLC;NMR (Conforms)
分子式:C26H23FIN5O4
分子量:615.39
溶剂:DMSO (20 mg/ml, warm)
性状:White solid
存储:-20°C
Activity (short version):MEK inhibitor
Function / Pharmacology:Trametinib is a highly potent (IC50 uMEK1 = 0.7 nM, pp-MEK1 = 14.9 nM)1 and selective MEK inhibitor displaying selective inhibition of proliferation in various BRAF mutant cancer cell lines (IC50 ACHN = 9.8 nM; IC50 HT-29 = 0.57 nM)2. It is approved for use against unresectable or metastatic BRAF-mutant melanoma alone or in combination with Dabrafenib. Trametinib can limit outgrowth of tumors without directly inhibiting tumor cell proliferation via abrogation of cytokine-driven expansion of monocytic myeloid-derived suppressor cells (mMDSC) through a mechanism involving CD8+ T cells.3,4 Trametinib also displays potent anti-arthritic effects.5
分子式:C26H23FIN5O4
分子量:615.39
溶剂:DMSO (20 mg/ml, warm)
性状:White solid
存储:-20°C
Activity (short version):MEK inhibitor
Function / Pharmacology:Trametinib is a highly potent (IC50 uMEK1 = 0.7 nM, pp-MEK1 = 14.9 nM)1 and selective MEK inhibitor displaying selective inhibition of proliferation in various BRAF mutant cancer cell lines (IC50 ACHN = 9.8 nM; IC50 HT-29 = 0.57 nM)2. It is approved for use against unresectable or metastatic BRAF-mutant melanoma alone or in combination with Dabrafenib. Trametinib can limit outgrowth of tumors without directly inhibiting tumor cell proliferation via abrogation of cytokine-driven expansion of monocytic myeloid-derived suppressor cells (mMDSC) through a mechanism involving CD8+ T cells.3,4 Trametinib also displays potent anti-arthritic effects.5