纯度:98% by HPLC;NMR (Conforms)
分子式:C20H19FN4O2S
分子量:398.45
溶剂:DMSO (>25 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):RIP2 kinase inhibitor
Function / Pharmacology:GSK583 is a highly selective and potent inhibitor of RIP2 kinase, IC50 = 5 nM human and IC50 = 2 nM rat.1 It also potently Inhibits isolated RPI3 kinase (IC50 = 5 nM) but is inactive against RIP3 in cellular assays due to a very low KM,ATP. GSK583 blocks NOD2 signaling by interfering with XIAP-RIP2 binding resulting in decreased cytokine and chemokine production.1,2