纯度:99% by HPLC (Agilent Poroshell 120 C18, 80/20 MeOH/water with 0.05% TFA; 0.8 ml/min);NMR (Conforms)
分子式:C25H22N6·2HCl
分子量:479.4
溶剂:DMSO or Water (up to 5 mg/ml)
性状:Orange-yellow solid
存储:-20°C
Activity (short version):ALK2 / ALK3 inhibitor
Function / Pharmacology:LDN-193189 2HCl is a potent and selective inhibitor of ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM), thereby inhibiting SMAD1/5/8 phosphorylation.1 Only weak inhibition of ALK4, ALK5, and ALK7 is observed. Promotes neuronal differentiation of human pluripotent stem cells.2-3 LDN-193189 HCl has also been used to examine the role of osteogenesis in prostate tumor metastases in bone.4