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IPA-3
- 英文名称：IPA-3
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11396
- cas：42521-82-4
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11396 |
| 用途 | 科研检测 |
| 英文名称 | IPA-3 |
| 包装规格 | 1MG |
| CAS编号 | 42521-82-4 |
| 别名 | IPA-3 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by TLC (methylene chloride; Rf=0.75);NMR (Conforms)
分子式:C20H14O2S2
分子量:350.45
溶剂:DMSO (25 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):PAK1 inhibitor
Function / Pharmacology:IPA-3 is a selective allosteric inhibitor of Group 1 p21-activated kinase (PAK1 IC50 = 2.5 μM)1 via covalent binding to the PAK1 regulatory domain preventing binding to the upstream activator Cdc422. IPA-3 has been shown to induce cell death in human leukemic cell lines3, significantly inhibit TGFβ1-induced prostate cell epithelial to mesenchymal transition4 and inhibits the growth of liver cancer cells5.
分子式:C20H14O2S2
分子量:350.45
溶剂:DMSO (25 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):PAK1 inhibitor
Function / Pharmacology:IPA-3 is a selective allosteric inhibitor of Group 1 p21-activated kinase (PAK1 IC50 = 2.5 μM)1 via covalent binding to the PAK1 regulatory domain preventing binding to the upstream activator Cdc422. IPA-3 has been shown to induce cell death in human leukemic cell lines3, significantly inhibit TGFβ1-induced prostate cell epithelial to mesenchymal transition4 and inhibits the growth of liver cancer cells5.
